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Compensation can become dangerous, because it is impossible to tell at exactly what dose diphenhydramine will become dangerous to one's health.

Dimenhydrinate dosages are roughly twice those of diphenhydramine dosages, as there are 29 mg of diphenhydramine per 50 mg of dimenhydrinate.

The full experience usually lasts 4 to 8 hours, but in cases of tolerance, drastically different effects can occur.

For some users, they may find themselves back at baseline within two hours.

This is accomplished by the antagonization of the neurotransmitter Acetylcholine - specifically, the muscarinic acetylcholine receptors - m ACh R).

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Cases of Diphenhydramine causing anticholinergic toxicity have been reported at doses as low as 400 mgs.One should never take a large dose before having tried a very small dose on its own previously. Speech and motor function is extremely difficult, and not much more than mumbling will come out at most.Diphenhydramine usually comes in 25 or 50mg dosages. If you close your eyes you'll think you're in a different place. Heart rate increases and it's difficult to get comfortable. You will think you're in one place at a different time of day, then quickly flash to another place.An injectable solution of Diphenhydramine may be used for immediate control of life threatening allergens such as bee stings, exposure to peanuts or latex, in addition to epinephrine.[1] [1] Diphenhydramine is an antihistamine, meaning that it blocks the effect of histamine at the H1 receptor sites, and is used for a wide range of effects, ranging from allergy and itching relief, to sleep aids, to nausea relief.However, in addition to its antihistamine effect, it also has powerful, anticholinergic effects.

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